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We chose MA in this comparison due to the availability of multiple structures for this protein.
Where there are multiple structures for a target determined by the SGC, often with different co-complexed ligands, these are included and frequently compared.
As noted above, sometimes it is important to include multiple structures for a given protein to have a good reliability in the predictions.
In Fig. 4 we show for this same set of proteins that using multiple structures for a given protein may improve the reliability of our method to an average error value of 48.4% (sensitivity 67.6% and specificity 63.9%).
Subjects were housed in 0.2-ha corrals that included multiple structures for climbing and several food distribution stations.
Since multiple structures for the various subunits were used, we could also factor in the number of times a particular protein was identified in a search ('repeats'repeats
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We found that assigning a mutation as (not) having a structural effect is very sensitive to precise structural details; where multiple structures are available for the same protein, one structure may indicate that a mutation has a value just below a cutoff while another structure has a value just above.
A non-systematic identifier was considered ambiguous within a database if it appeared in multiple records in the database, i.e., if multiple structures were provided for the same identifier.
This topic can be introduced through exploration of a set of crystal structures for proteins for which multiple structures have been solved.
Of these, we removed the superfamilies 'Lipocalins' and 'Trypsin-like serine proteases,' which were not structurally consistent enough to permit a multiple structure alignment for training HMMER or the SMURF variants, and which were broken into distinct superfamilies by (Daniels et al., 2012), with the result that 11 superfamilies containing barrels were selected.
The design had to be fluid to accommodate the long-term life cycles of certain plants, says Corner, who describes his approach as "time-based, capable of absorbing and reflecting nature's role". Over the next decades, the grand master plan calls for multiple structures and playing fields, wetlands, creeks, and wildlife habitats.
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