The validity of these predictions was further enhanced by comparison, based on multiple alignment and structural information, to published orthologous counterparts.
However, these studies are hindered by the lack of adequate detectors that can provide multiple frames of detailed structural information on the required millisecond time scale at the extremely high count rates available at the APS.
In this study, we have demonstrated that the specificity and sensitivity of protein subcellular localization prediction can be improved by incorporation of multiple predictive methods and structural information.
The method is fast and simple enough to simultaneously use structural information of multiple proteins of a target family.
Hence, a multiscale analytical approach, which combines bone structural information at multiple scales to the remodeling cellular activities, could form an efficient, accurate and beneficial framework for the prognosis of changes in bone properties due to, e.g., bone diseases.
It is furthermore of interest to use the homology information from multiple structural alignments of ncRNA candidates for interaction prediction.
The novel KLK amino acid sequences were aligned along with three KLKs with resolved tree-dimensional structure using PROMALS3D [101], [101], a multiple sequence alignment program which incorporates structural information in order to improve alignment accuracy.
This exemplifies the importance and effectiveness of multiple-dimensional use of the structural information of templates in developing fold-recognition techniques.
Prioritization of which of the multiple variants listed in the SNP database to study was informed by protein structural information, but remained relatively simplistic.
Despite the fact that multiple binding partners of Cby have been identified, structural information of Cby is still limited.
