Its ability to infect under these conditions has been suggested that it may use unique pathogenic mechanisms to facilitate integrated responses to the multiple stresses it encounters within the phagosome.
Thus, as a unique cyclic-di-GMP signaling transduction gene in M. tuberculosis, Rv1354c may play an important role in sensing extracellular signals that facilitate integrated responses to multiple stresses encountered by M. tuberculosis within the phagosome.
We propose that activation of a slow growth and a stringent metabolic response confers resistance to multiple stresses (oxidative, temperature, pH), as well as both nutrient limitation and nutrient excess within this niche.
Additionally, the complex inter-cellular crosstalk within the tumor niche, mediated by cytokines, redox-sensitive danger signals (HMGB1) and exosomes, under the pressure of multiple stresses (oxidative, inflammatory, metabolic), greatly contributes to the malignant phenotype.
Some extremophiles are adapted simultaneously to multiple stresses (polyextremophile); common examples include thermoacidophiles and haloalkaliphiles.
It is noteworthy why the overproduction of Pyk contributes to the resistance to multiple stresses.
"The workers have been through multiple stresses," Dr Shigemura says.
(4) The number of accelerated stresses, which includes single stress, double stresses and multiple stresses (the number of test stresses greater than or equal to three). .
Generally, abiotic stresses are studied, analysed, and even reviewed separately; rarely multiple stresses are analysed together.
We also characterized dimerization pattern within the leucine zipper motif and gene structures, and obtained tissue-specific gene expression profile and genes expression profile responding to multiple stresses including environmental factors, phytohormones, and heavy metals.
