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In models of multiple pathogen strains, it has been shown that in cases where the deterministic model predicts the coexistence of multiple strains, the stochastic model predicts the extinction of one or all strains [21], [22].
In the case of multiple phenotypes (which could also be in multiple strains) the assumption is that the phenotypes are measuring the effect of the same polymorphism between progenitor strains for the cross.
Based on our findings in the two women with multiple strains, the detection of a different virus in one or more body sites suggests that a new strain was occasionally able to overgrow the existing one so that the original one became undetectable.
Because many indels are present in multiple strains, the total number of indels mapped to the genomes is 146,762.
Furthermore, in all cases where a specific insertion sequence was present in multiple strains, the strains containing that insertion belonged to the same phylogenetic lineage, suggesting that occurrence of independent insertions in the same nucleotide position but in different lineages by convergent evolution, although plausible, is very unlikely.
Similar(55)
We first presented a model of the within-patience persistence of HIV quasispecies, by extending to multiple strain the Perelson's standard model [ 13].
In the case of multiple strains, this means the allele difference causing the QTL occurs in the same gene between the strains crossed in each population.
The differential presence of the 71 GIs across multiple strains demonstrates the importance of these mobile elements for shaping the genetic composition of individual strains and populations within this bacterial species.
If these occurred in multiple strains at the same genomic location, the gene contents of the inserts were compared to determine if they represented distinct GIs.
If multiple strains represented the same profile, the strains isolated in different years or different regions were included.
In order to substantially improve protection against the flu, the report concluded, researchers need to create a vaccine that targets antigens shared by multiple strains of the virus, such as the HA stalk, nucleoprotein, and the matrix 2 protein.
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