Sentence examples for multiple step mutation from inspiring English sources

Therefore, a multiple step mutation cancer theory (mutation latent mutation…to a cancer) [ 5 ] and DNA repair theory were developed to match the actual cancer incidence [ 12 ].

We assumed that microsatellite loci follow a two-phase mutation model (intermediate between the IAM and SMM models) with 70% single-step mutations and 30% multiple-step mutations.

We assumed that microsatellite loci follow a two-phase mutation model with 70% single-step mutations and 30% multiple-step mutations.

This corresponds well to the above observations of larger potential for adaptation to challenging environments in multiple-step mutations (cf. Figure 5 and discussion thereof).

Following the authors' recommendation for microsatellite data, we used a two-phase model (TPM) with 95% single-step mutation and 5% multiple-step mutations (and a variance among multiple steps of 12).

We assumed a two-phase mutation model with 95% stepwise mutations, 5% multiple-step mutations, and a variance among multiple steps of 12 as recommended for microsatellites by Piry et al. [ 40].

Coalescent simulations were performed for three possible mutation models (infinite alleles model, stepwise mutation model, and the two-phase model, which allows multiple-step mutations), and resulting distributions were used to calculate average expected heterozygosity.

Using these estimates, we compare the differences in the DFEs resulting from mutations covering one-, two-, and three-nucleotide steps from the wild type showing that multiple-step mutations harbor more potential for adaptation in challenging environments, but also tend to be more deleterious in the standard environment.

The present experiments were begun after finding a mutation in fur gene codon 3 (change of Arg to Ile; "furR3I") in an H. pylori strain that had undergone multiple steps of mutation and selection for increased resistance to metronidazole (Mtz) [20].

Carcinogenesis and cancer progression are multiple step processes that involve genetic mutation, cell-cell communication, and cell micro-environment interactions.

Several lines exhibited multiple step changes from the progenitor sequence, although it is unclear whether these are multi-step mutations or multiple single step mutations.