Several lines exhibited multiple step changes from the progenitor sequence, although it is unclear whether these are multi-step mutations or multiple single step mutations.
Since this pathway encompasses multiple steps, changes not only in the clearance but also in the initiation could concur for the accumulation of autophagic vesicles observed.
Following a signal from the cumulative count of conforming (CCC) control chart, the performance of the proposed monotonic change-point estimator is next evaluated by comparing its performances to the ones designed for step-changes and linear-trend disturbances through extensive simulation experiments involving different single step-changes, linear-trend disturbances, and multiple-step changes.
Moreover, a process parameter may change due to multiple-step changes.
The problem of estimating the time of a change in a univariate binomial distribution for different change types of step change, linear-trend disturbance (drift), multiple-step changes, monotonic change, and other change types defined as a combination of the above has been addressed in the literature.
The key is to act greatly, taking multiple steps to change things, even if we're not sure if they'll work.
The reciprocating cylinder was operated at 10 dips per minute (dpm) with multiple steps of media change over to simulate the human gastrointestinal environment.
We considered three scenarios of changes, a step change, a linear trend, and a multiple change when the number of changes is known.
In this scenario, the changes are in the form of a step change, a linear trend and a multiple change with known number of changes.
Table 7 indicates that the Bayesian estimate of a step change outperforms other Bayesian estimates, linear and multiple, where there is a step change in the process parameter.
