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Moreover, among the 35 differentially expressed proteins, 10 proteins were present as multiple spots on the 2-DE gels, with one spot representing an isoform (Figure 4A).
Doctors inject it into multiple spots on the neck, relieving sometimes disabling pain for weeks or months.
A single treatment, consisting of injections into multiple spots on the leg muscles on the same day, is expected to last for several years, if not longer, said Jorn Aldag, chief executive of uniQure.
Compositional analysis was carried out at multiple spots on the gold-colored layer by EDX.
First, interview conducted with actual professionals in charge of conducting hammering tests revealed that they were, in fact, more focused in hitting multiple spots on the structure at high speed and looking for sounds that stands out rather than relying in past experiences and knowledge.
After consent was obtained, blood was collected in multiple spots on a single filter paper from each participant and placed in a drying box with desiccant overnight.
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First, a linear mixed effects model was fitted to the normalised log ratios of each gene, with the microarray slide as a random effect to take into account the correlation between multiple spots of each gene on the same slide.
Also Vellekoop et al. showed in his pioneering work optimization on multiple spots [6].
To measure binding on multiple spots a 2D array is more suitable and a lock in camera array matched to this format is presently being tested; in this case the well depth is rather smaller and we need to evaluate whether the sensitivity is still limited by the optical system.
A second analysis, filtering on confidence, was possible because genes were represented on the chip by multiple spots.
Unique proteins, when analyzed on the 2D gel, often show multiple spots due to posttranslational modifications.
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