Sentence examples for multiple sporadic malignancies from inspiring English sources

Germline and somatic PTEN mutations are found in Cowden syndrome (CS) and multiple sporadic malignancies, respectively.

But the contribution of heredity to the causation of sporadic malignancies, like cervical cancer is unclear.

Heterozygous disruption of Beclin 1 increased the incidence of sporadic malignancies in mice, including lymphoma [19], [20].

Microsatellite instability has been observed in a variety of sporadic malignancies, but its existence in sporadic ovarian cancer has been the subject of conflicting reports.

Out of 10, 5 PTPN11 mutations found in our NS patients with a malignancy were previously reported as somatic mutations in sporadic malignancies (Table 2).

In addition to these systematic problems, there were multiple sporadic ones.

Multiple sporadic cases of nonindigenous CHIKV infection have been reported in China.

These observations should provide a novel pathway which involves manipulation of ATP and mitochondrial function in the treatment of both these heritable and sporadic malignancies.

Moreover, some recent reports have demonstrated the correlation between the subtelomeric DNA methylation to the development of several degenerative disorders and some sporadic malignancies [ 25– 27].

Indeed, half of the NS patients with cancer are carriers of a mutation that has previously been reported as a somatic mutation in sporadic malignancies (Table 2).

Interestingly, recent evidence suggests that these pathways are deregulated in multiple sporadic cancers (Beroukhim et al, 2010).