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Whether the multi-reactivity was due to cross reactive T cells or the presence of multiple specificities in the T-cell lines was not investigated.
Thus, these 3 patients were considered to have multiple specificities in their first available sample and were included in the multiple specificity group for analysis.
This observation is consistent with the possibility of a sampling issue in a substantial proportion of the 19 with multiple specificities in the earliest positive serum.
Here we have examined the mechanisms of multiple specificities in two date hub-like hub proteins.
They identify multiple specificities in peptide data by performing two essential tasks simultaneously, alignment and clustering, and therefore find biologically relevant binding motifs that cannot be described well with a single PWM.
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This intriguing p53 example demonstrates the roles of IDRs in determining multiple specificities associated with the one-to-many binding mode, where remarkable conformational changes enable very distinct surfaces to be formed for binding to different partners.
We conclude that the expression system reported herein will represent a valuable tool to produce human SIgA Ab of multiple specificities against H. pylori antigens involved in colonization and persistence.
T cells of multiple specificities, including self-specificities, are a frequent finding in inflammatory joint diseases such as Lyme arthritis and rheumatoid arthritis [ 14- 17].
In 14-3-3 14-3-3 14-3-3rencesubtle4-3-3 conformation andifferencesinding 14-3-3 14-3-3 14-3-3tiple speconformation
No significant differences in gender, race, or age at diagnosis were found between the patients with a single initial autoantibody and those with multiple specificities.
Such chameleon sequences likely underlie the multiple specificity binding sites common in p53.
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