Exact(31)
Consistent with reports on the development B19V specific cellular response in adults with an acute infection, we identified a B19V specific CD8+ T-cell response with multiple specificities, which gradually decreased over time [5], [10].
Eventually, a cocktail of inhibitors or a polyvalent inhibitor needs to be used, since many infectious agents express multiple specificities.
We conclude that the expression system reported herein will represent a valuable tool to produce human SIgA Ab of multiple specificities against H. pylori antigens involved in colonization and persistence.
Therefore, combining multiple specificities within a single protein may simplify the task of protein transport.
After passing through this autoantigenic bottleneck, the initial humoral autoimmune response then usually diversifies, with the sequential development of autoantibodies binding multiple specificities before clinical presentation and diagnosis.
Whether the multi-reactivity was due to cross reactive T cells or the presence of multiple specificities in the T-cell lines was not investigated.
Similar(29)
The second approach is implemented in tools using multiple position-weight matrices (also known as position-specific scoring matrices) to represent multiple specificity profiles obtained by various techniques, e.g. mixture model optimization (Kim et al., 2011) or Gibbs sampling (Andreatta et al., 2012).
EGFR promoter is characterized with GC-rich, and TATA-less, and harbors multiple specificity protein 1 (Sp1) binding sites [33].
Such chameleon sequences likely underlie the multiple specificity binding sites common in p53.
In any event, however, the p53 DBD demonstrates that even proteins generally thought to be well folded, structural changes can still occur in association with multiple specificity.
We have compared our results with a recently developed tool (Kim et al., 2011) based on PWMs called Multiple Specificity Identifier (MUSI).
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