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In this way each of the various p53 genotypes (+/+, -/-, +/-, +/M/M-/M, M/M) represents the average of multiple specific genetic backgrounds.
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These complex differences are likely brought about by the combined activity of transcription factors and microRNAs (miRNAs) that regulate expression of multiple genes and specific genetic programs.
Dissemination might follow an allodemic pattern, corresponding to the spread of multiple specific clones or genetic elements.
Therefore, it is likely that multiple DLB-specific genetic determinants still have to be identified.
Furthermore, the study underscores the relevance of empirically testing the sensitivity of mutant tumors to multiple targeted agents as specific genetic alterations may dictate the tumor response to targeted therapy.
The study is thus an analogue to a likely use of the technique - the PCR amplification and sequencing of specific genetic regions from multiple individuals of a single species.
Multiple myeloma (MM) is a plasma cell malignancy characterized by specific genetic and epigenetic changes.
The failure to identify specific gene variants for most cases of autism has been attributed to many potential factors including complex interactions of multiple genes, a heterogeneous disorder with multiple causes converging on the autistic phenotype, or epigenetic factors not related to specific genetic mutations or polymorphisms [2], [3].
However, previous studies that investigated plant genetic diversity in ecosystems used plants that varied in multiple, usually unknown, genetic traits, which made it difficult to identify specific genetic traits in plants that can influence the whole ecosystem.
The huge amount of AD specific genetic data accumulated in the past decade also indicates involvement of multiple pathways wherein each gene confers only a modest risk.
Genetic tests are currently available for specific genetic disorders, but the Wellcome Trust Case Control Consortium is looking at the more mild and multiple genetic variations which combine with environmental factors to give a person an increased risk of developing a disease.
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CEO of Professional Science Editing for Scientists @ prosciediting.com