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Sequence data from multiple species will be necessary to distinguish neutral vs. adaptive evolutionary processes.
Long-term safety and toxicity studies in multiple species will be necessary to progress for studies in humans.
Comparative analyses of these regulators across multiple species will validate our predictions by their appearance in another species.
Future analyses of multiple species will clarify the evolutionary mechanisms of the coding and regulatory sequences more precisely.
These results suggest that studies of combinatorial TF binding in primary tissues from multiple species will provide valuable datasets that are currently missed bin current integrative analyses.
Future detailed studies focusing on multiple species will benefit from inter-species genomic DNA hybridizations in order to determine spots that are most affected by sequence divergence [ 2].
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These gene models produce reliable annotations for conserved genes as well as genes that are present in multiple species but will lack lineage specific genes where sources of genetic novelty add to the genome, will misidentify rapidly evolving sequences, and will neglect isoforms that may offer alternative molecular functions.
As more genomes are assembled and richer recombination and polymorphism data become available for multiple species, we will be able to develop a deeper understanding of the causes and effects of BDS across the tree of life.
Determining orthologous genes in multiple model species will greatly enhance knowledge of evolutionary patterns and processes [10], and promote research in non-sequenced species.
23 The identification of drought responsive USP genes from multiple plants species will present an array of research tools for genetic manipulation of plants for drought tolerance.
Investigating the full breadth of Lhx3/4 functions in multiple ascidian species will be required in order to determine the relationship between Lhx3/4 duplication and re-wiring of Mesp regulation.
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