Of 85 nodes with a bootstrap support value >80%, 65 contain only 59-be sites from the same species and 20 contain 59-be sites from multiple species, indicating transfer of gene cassettes between species.
The consolidated data were deemed "strong" if multiple studies in multiple species indicated similar BPA-associated effects, "limited" if some but not most studies indicated a similar end point or if studies disagreed across species, or "inconclusive" if studies were limited in number or had only been done in one species or in vitro.
Similar to the 2007 expert panel, we considered the evidence to be strong when multiple studies in multiple species indicated a similar effect of BPA on a reproductive tissue or end point, even if concordance was not 100% across all studies, given that species and strain differences can lead to differences in dose response and magnitude of effect.
Similar to the 2007 expert panel report, we considered the evidence to be strong when multiple studies in multiple species indicated a similar effect of BPA on a reproductive tissue or end point, even if concordance was not 100% across all studies, given that species and strain differences can lead to differences in dose response and magnitude of effect.
The high representation of small individuals in multiple fish species indicates the importance of the artificial floodplain channel as habitat for early life stages.
Putative orthologues of PIPKIγ_i5 were identified in multiple vertebrate species, indicating that the function of PIPKIγ_i5 is most likely conserved.
Therefore, identification of common structural differences between isoforms in multiple species can indicate common functional adaptation.
High conservation of noncoding sequences across multiple species may indicate the presence of functional elements.
The DegTri is listed in Fig. 1A; other two are listed in Supplementary Fig. S1A and B. Lattice points containing sequences from a single species are coloured to indicate the species, whereas those containing sequences from multiple species are indicated in black.
On the BLSOM, lattice points containing sequences from a single species are indicated in a color specifying the species; those containing sequences from multiple species are indicated in black.
