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Sequence conservation among multiple species has been proven to constrain functional TFBS [16], [17], [40].
This lack of phenotype across multiple species has led to the hypothesis that the three mammalian Anp32 orthologues are functionally redundant such that no one factor is essential for development.
The potent developmental toxicity of dioxin in multiple species has been known for a number of years.
Having a complete set of orthologous tRNAs across multiple species has enabled the detection of several functional changes in nuclear tRNA genes.
Supporting this notion, our analysis of DBC1 and CCAR1 from multiple species has established evidence that both proteins have evolved from one common nematode ancestor, LST-3.
Conservation across multiple species has been recognized as a key indicator of functional importance [ 27, 28], although PDE4 s are known to be temporally and spatially differentially regulated [ 14, 29, 30].
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Recent studies in multiple species have unveiled diverse roles of the FT/TFL1 gene family in developmental processes other than flowering regulation.
Pre-clinical studies in multiple species have confirmed the safety of H2S-releasing NSAIDs, supporting the initiation of human clinical trials.
Competent reservoirs for TBEV are known to be small forest mammals, insectivores, and livestock species, but the role of passerines and their ticks in the transmission of the infection is not well understood, even though multiple species have been detected positive38.
By constructing a family tree of 180 species of rove beetles — only a small number of which resemble and live among ants — they have discovered that multiple species have evolved ant-like characteristics independently of one another over the past hundred million years.
Several studies, that have combined data from multiple species, have found that the first intron is,on average, longer that other introns [20].
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