To remedy this, we performed large-scale analyses of microarray hybridisations with male and female RNA from multiple somatic mouse tissues including kidney, liver, lung, eye, and two brain regions: the striatum and hippocampus.
GDISR confers systemic protection of somatic tissues against multiple stress factors and suggests that innate immunity plays an important role in adjusting somatic endurance to reproduction.
Recently, piRNA-like molecules have been identified in somatic tissues from multiple organisms (Ro et al. 2007; Ghildiyal et al. 2008; Li et al. 2009; Yan et al. 2011).
Strong gain-of-function (GOF) mutations that arise in somatic tissues can result in multiple types of cancer (Hanahan and Weinberg, 2011).
It is also possible that indeed the chimerism observed in somatic tissues is true chimerism, though multiple lines of evidence suggest this too is unlikely.
The differential expression patterns of MnGus in the embryo, ovary and other somatic tissues suggest that the gustavus gene performs multiple physiological functions in the oriental river prawn.
DNA methylation patterns are established during embryogenesis and then faithfully maintained in differentiated tissues, enabling preservation of cellular identity through multiple somatic divisions.
For example, an epimutation of the tumor suppressor gene MLH1 was found in both normal somatic tissues and spermatozoa of a patient with multiple cancers, indicating the potential for transmission of the epimutation to offspring (Suter et al. 2004).
However, in somatic tissues only female-biased genes, including those co-expressed in multiple tissues, showed elevated ratios of non-synonymous substitutions.
New mutations could change pleiotropic influence on the genetic system, even in somatic tissues.
