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We observed the same pattern in the human data, although in this case the multiple somatic origins of the cell lines of origin contribute to the higher level of variation.
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The prevalence of multiple somatic symptoms is high in primary and hospital outpatient populations.
Preliminary variant pathogenicity classification was carried out by automated searching of multiple somatic and germline mutation databases and in silico prediction of the functional impact of each variant.
a, DNA methylome profiles of multiple somatic tissues from the Roadmap Epigenomics Project (http://www.roadmapepigenomics.org/) are displayed on the WashU Epigenome Browser (http://epigenomegateway.wustl.edu/browser/).edu/browser/
PACCs had multiple somatic mutations with some targetable with available drugs.
In the meantime, patients with chronic, multiple somatic symptoms who are still waiting for a diagnosis would be vulnerable to misdiagnosis as psychiatrically ill.
A principle difference exists between single vs. multiple somatic alleles.
This resulted in an average linear correlation coefficient of R2≈0.87, reflecting heterogeneity of iPSCs of different somatic origins.
Although their disease has features shared with single somatic allele patients, most notably the preferential enrichment of somatic alleles in memory T cells [9], [10], other important features of their phenotype are specific to multiple somatic alleles.
These naturally occurring mutations derive from germline and somatic origins.
Disruptive disorders, multiple somatic symptoms (somatic complaints), or both precede adolescent MDD before developing adult BPD.
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