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In this work we have studied reprogramming by injecting multiple somatic nuclei into mature oocytes in first meiotic prophase.
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Consistent with this observation, ESC multikaryons that contained multiple human B cell nuclei (as illustrated in Figure S4A) usually showed coordinated BrdU labeling patterns in all somatic nuclei.
"Embryonic stem cells generated by nuclear transfer of human somatic nuclei into rabbit oocytes".
A consistent feature of sperm nuclei is its exceptionally compact state in comparison with somatic nuclei.
Precise anatomical data on the development of human oculomotor somatic nuclei (OSN) remain rare.
There are 959 somatic nuclei in an adult hermaphrodite, and consequently considerably less in its various tissues.
In the far future, perhaps somatic nuclei could be reprogrammed directly.
The prevalence of multiple somatic symptoms is high in primary and hospital outpatient populations.
Despite remarkable progress in the cloning of mammals using different somatic nuclei, there is little information available regarding the choice of donor cell origin (type and/or gender) for mammalian somatic cell nuclear transfer.
The presence of both germline and somatic nuclei in these cells requires different strategies to target DNA to the desired compartment.
Our data demonstrated that telophase enucleation is beneficial to early embryo development when bovine somatic nuclei are transferred by subzonal injection.
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