Sentence examples for multiple somatic mutations from inspiring English sources

Unrecognized contamination will ordinarily be mistaken as evidence towards multiple somatic mutations and may be associated with the development of diseases, like the late stage of cancer.

Although a few instances of multiple somatic mutations have been described for other primary immune deficiencies no WAS patient described at that time had more than one somatic allele (Discussion).

The hallmarks of AML are multiple somatic mutations, including genetic rearrangements that affect signal transduction and gene expression.

Carcinogenesis typically involves multiple somatic mutations in caretaker (DNA repair) and gatekeeper (tumor suppressors and oncogenes) genes.

These include multiple somatic mutations and the presence of arginine residues at critical positions in the antigen-binding site.

For example, as many as 12 core pathways are disrupted in the majority of pancreatic cancers through multiple somatic mutations [ 3].

We have presented here an easily implemented but highly effective strategy for enriching true somatic SNVs in exome-sequencing data, using consensus between multiple somatic mutation prediction algorithms.

A naive yet logical strategy could be to employ multiple somatic mutation prediction algorithms and to select variants for follow-up based on overlapping predictions, obviating the need to make a priori assumptions about the relative performance of each program.

The disadvantage for WASPΔVCA germ line thymocytes is apparently enormous since it is sufficient to drive multiple independent somatic mutations to detectable frequencies.

Cancer is a disease of genome alterations that arise through the acquisition of multiple somatic DNA sequence mutations.

Genome-wide profiling of structural DNA alterations in ALL identified multiple sub-microscopic somatic mutations targeting key cellular pathways and demonstrated evolution in genetic alterations from diagnosis to relapse [ 29].