FAs, and pFAs in particular, usually have multiple (chronic) somatic diseases, psychiatric disorders and social problems [ 2, 7, 8].
The common deletion was recognized early on as the cause of DiGeorge Syndrome and velo-cardio-facial syndrome (and recently the 22q11 deletion syndrome) encompassing multiple somatic conditions, including congenital heart disease, velopharyngeal insufficiency, immune deficiency, facial dysmorphism and intellectual disability [ 22– 22].
The highest incidence is reported for geriatric inpatients [ 1], which often have several risk factors [ 2] at the same time and suffer from multiple diseases: The prevalence rate of five or more somatic diseases for persons aged 70 years and above has been reported in the Berlin Aging Study to be 88% [ 3].
Unrecognized contamination will ordinarily be mistaken as evidence towards multiple somatic mutations and may be associated with the development of diseases, like the late stage of cancer.
Cancer, as a disease of genome alterations, arises through the sporadic acquisition of multiple somatic variations (4).
Cancer is a disease of genome alterations that arise through the acquisition of multiple somatic DNA sequence mutations.
The prevalence of multiple somatic symptoms is high in primary and hospital outpatient populations.
BRAF gene mutations are frequently seen in both inherited and somatic diseases.
Large-scale genomic studies have identified multiple somatic aberrations in breast cancer, including copy number alterations and point mutations.
Pediatric osteosarcoma is characterized by multiple somatic chromosomal lesions, including structural variations (SVs) and copy number alterations (CNAs).
