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The common deletion was recognized early on as the cause of DiGeorge Syndrome and velo-cardio-facial syndrome (and recently the 22q11 deletion syndrome) encompassing multiple somatic conditions, including congenital heart disease, velopharyngeal insufficiency, immune deficiency, facial dysmorphism and intellectual disability [ 22– 22].
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Affective disorders are prevalent in different somatic conditions and influence somatic symptom bother and quality of life.
The prevalence of multiple somatic symptoms is high in primary and hospital outpatient populations.
Concomitant somatic conditions are usually considered an important risk factor of PJI [11, 12].
Large-scale genomic studies have identified multiple somatic aberrations in breast cancer, including copy number alterations and point mutations.
Pediatric osteosarcoma is characterized by multiple somatic chromosomal lesions, including structural variations (SVs) and copy number alterations (CNAs).
Since multiple somatic and psychological symptoms frequently coexist in OFP and TMD patients, case-finding instruments have been developed for initiating diagnostic procedures that facilitate optimized treatment.
The objective was to investigate the role of psychiatric and somatic conditions in incident and persistent insomnia.
In the meantime, patients with chronic, multiple somatic symptoms who are still waiting for a diagnosis would be vulnerable to misdiagnosis as psychiatrically ill.
A principle difference exists between single vs. multiple somatic alleles.
Although their disease has features shared with single somatic allele patients, most notably the preferential enrichment of somatic alleles in memory T cells [9], [10], other important features of their phenotype are specific to multiple somatic alleles.
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