Sentence examples for multiple somatic alterations from inspiring English sources

Remarkably, Taylor et al. [ 6] performed focused exon resequencing in 218 prostate cancer tumors and identified multiple somatic alterations in the androgen receptor (AR) gene as well as its upstream regulators and downstream targets.

Large-scale genomic studies have identified multiple somatic aberrations in breast cancer, including copy number alterations and point mutations.

Pediatric osteosarcoma is characterized by multiple somatic chromosomal lesions, including structural variations (SVs) and copy number alterations (CNAs).

Cancer, as a disease of genome alterations, arises through the sporadic acquisition of multiple somatic variations (4).

Cancer is a disease of genome alterations that arise through the acquisition of multiple somatic DNA sequence mutations.

While somatic genetic alterations in the tumor are the primary determinant of response to targeted therapy, multiple somatic genetic abnormalities are present in each tumor so both finding the critical mutations and proving that these were in fact driving tumorigenesis was and remains challenging.

Gene transfer permits both germline and somatic alterations.

Genetic somatic alterations are fundamental hallmarks of cancer.

Gene fusions represent an important class of somatic alterations in cancer.

Colon cancer is a genetic disease, propagated by the acquisition of somatic alterations that influence gene expression.

These PanIN lesions are in turn associated with somatic alterations in canonical oncogenes and tumor suppressor genes.