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This suggests that (iii) multiple somatic alleles may indicate that the germ line allele has a dominant negative effect.
Thus, a finding of multiple somatic alleles in a single individual serves to "flag" an inherited allele harboring unique information.
A principle difference exists between single vs. multiple somatic alleles.
A recent publication reports on another WAS patient with multiple somatic alleles [30], and thus, the brothers described here are the second and third reported cases of multiple somatic alleles in WAS.
In contrast, the presence of multiple somatic alleles in an individual patient indicates that a more deterministic process is occurring.
WASP mRNA in the patients' T cells had varying size, indicating that multiple somatic alleles are indeed expressed.
Similar(52)
To distinguish between this possibility and that of multiple transcribed somatic alleles, we subjected amplified reverse-transcribed RNA and amplified genomic DNA to size analysis by high resolution electrophoresis.
The prevalence of multiple somatic symptoms is high in primary and hospital outpatient populations.
PACCs had multiple somatic mutations with some targetable with available drugs.
In the meantime, patients with chronic, multiple somatic symptoms who are still waiting for a diagnosis would be vulnerable to misdiagnosis as psychiatrically ill.
Secondly, the somatic alleles are diverse.
More suggestions(15)
multiple functional alleles
multiple somatic origins
multiple somatic divisions
multiple somatic nuclei
multiple somatic changes
multiple somatic complaints
multiple somatic impairments
multiple somatic pains
multiple somatic diseases
multiple somatic aberrations
multiple somatic cells
multiple somatic lineages
multiple somatic alterations
multiple somatic systems
multiple somatic illnesses
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