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At dissection, the abdomen contained multiple solid tumor lesions (median, n = 10/mouse; range, 4 to 17).
These data indicate that aberrant demethylation of multiple, physiologically repressed proto-oncogenes occurs in a coordinated fashion in individual tumors from multiple solid tumor types.
AR-42 (previously called OSU-HDAC42) is a novel hydroxamate-tethered phenylbutyrate derivative [16], [17] with in vitro and in vivo activity in multiple solid tumor models [18], [19], [20], [21] and more recently, in mouse and canine mast cells [22].
These findings confirm those of other groups, which have demonstrated that ATO induces apoptosis of multiple solid tumor cell types [ 31- 34].
76 A Phase I dose escalation/expansion study in multiple solid tumor types is being conducted to evaluate dose-limiting toxicities.
Perhaps most importantly, we show that the optimized LLE substrate probes provide sufficient signal and contrast that they can be used in existing surgical workflows for real-time imaging of multiple solid tumor types using the da Vinci Surgical System (Intuitive Surgical, Sunnyvale, CA; www.intuitivesurgical.com/products/davinci_surgical_system/) that is currently in use in hospitals worldwide.
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The overexpression of SCD-1 in multiple solid tumors associates with poor survival in cancer patients.
Human Vδ2 γδ T lymphocytes killed multiple solid tumors, even displaying comparable therapeutic efficacy with anti-tumor chemical-cis-platinum in an adoptive experiment in both nude and SCID murine model shown in present study.
To date, expression of PD-L1 is detected in multiple solid tumors, including melanoma, lung, breast, and ovarian cancers, as well as in myeloma, T cell lymphoma, etc. (Brown et al., 2003; Wherry et al., 2003; Ghebeh et al., 2006; Hamanishi et al., 2007; Liu et al., 2007; Hino et al., 2010).
Moreover, a recent report shows that Polycomb repression signature genes can predict clinical outcome of multiple solid tumors [24].
Parthenolide has been shown to have pre-clinical activity in AML [15], CLL [16], as well as multiple solid tumors [17] [19].
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Justyna Jupowicz-Kozak
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