Sentence examples for multiple solid malignancies from inspiring English sources

Downregulation of c-Met may be due to a positive feedback loop, as autocrine/paracrine mechanisms of c-Met hyperactivation including receptor and/or HGF overexpression in multiple solid malignancies has been shown.

This dataset consisted of serial PET/CT scans aquired across four study sites of 53 advanced-stage cancer patients with multiple, solid malignancies on the dose escalation stage of a phase 1 clinical trial of a novel drug.

Polo-like kinase 1 (Plk1) is a member of the PLK family of serine/threonine kinases crucial to the cell division cycle, which has been postulated to induce oncogenesis in multiple solid and hematologic malignancies.

In light of current clinical trials evaluating the efficacy of anti-DKK-1 antibody therapies in multiple myeloma and solid malignancies, the measurement of DKK-1 in prostate cancer may gain clinical relevance.

Although they can form solid masses, lymphoma and multiple myeloma originate as "liquid tumors" and, unlike true solid malignancies, they are unresectable regardless of stage.

The proteasome inhibitor bortezomib is an FDA-approved drug for the treatment of multiple myeloma, but has shown only little single-agent activity in solid malignancies such as HNSCC while being effective in combination with other treatment options.

Demethylating agents, including 5-azacytidine, are already being used in the management of haematological malignancies and myelodysplastic syndrome, and are in clinical trials for multiple solid tumours.

In light of anti-DKK-1-antibodies currently under clinical evaluation for patients with advanced multiple myeloma, these data warrant further research on the role of DKK-1 in solid malignancies, including prostate cancer.

In addition, ROR1 is critically involved in progression of a number of blood and solid malignancies.

Top three solid malignancies were lung (27.2 %), followed by breast (12.5 %) and Bowel (11.8 %).

However, the expression of ROR1 has been seen in numerous blood and solid malignancies.