Multiple small clinical trials investigating the effect of antioxidant vitamin E, vitamin C, and beta-carotene on glycemic control in diabetic patients yielded inconsistent results [ 111– 115].
Results of multiple smaller clinical trials and recent larger randomized controlled clinical trials advise against the use of both high and low molecular weight starch-based solutions in the care of critically ill patients, because they appear to increase morbidity and rates of renal dysfunction.
Gemcitabine has been used in combination with platinum agents and fluoropyrimidines in multiple small phase II trials, but it was not until 2009 that a regimen that can be considered a standard emerged.
The same two single-digit numbers served as the cue for product, multiple, small distance, and large distance trials (e.g., "3·9").
In the crucial conditions (i.e., non-matching product, multiple, small distance, and large distance trials), several criteria for stimulus selection were adopted in order to minimize the occurrence of confounds.
Historically, evidence from small trials has suggested multiple cannulated screws were the optimal implant; however, newer studies and implant designs warrant reevaluation of screws as the gold standard among surgeons.
Recent clinical trial successes have been achieved through multiple small advances, improved understanding of immunology and emerging technologies.
8, 9 We have known for a considerable time that small trials may yield exaggerated treatment effects and spuriously small P-values compared to larger trials or multiple trials pooled in a meta-analysis.
He found buildings crammed with multiple small studios.
