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Since the genetic basis of grain Zn is complex with the involvement of multiple small effect genes/QTLs and significantly influenced by the environment, the choice of appropriate breeding methods, crossing programs, individual plant selections and field evaluation processes are critical for the successful development of high-Zn rice.
The second one is that the gene expression is regulated by multiple small effect eQTLs that are not detectable with a small population size.
If the origin of the RM-specific genic profile of H3K14ac is genetic, it is likely driven by multiple small effect loci.
We conclude that the postharvest disorder FD is controlled by multiple small effect QTLs and that it will be very challenging to apply marker-assisted selection based on these QTLs.
This study clearly demonstrates that this postharvest disorder is controlled by multiple small effect QTLs, unlike fruit quality attributes, such as firmness and skin biochemical composition that are controlled by small and medium effect QTLs.
Additionally, or alternatively, AJ alleles may have been positively selected during growth without drugs, reflecting the possible action of multiple (small effect) genes that underlie the faster growth of AJ compared to AS parasites, observed routinely in previous experiments [ 41, 42].
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A large body of evidence from various studies suggests that this sterility is often asymmetric (ie concerns the males obtained through only one of the two types of crossings), and results from the accumulation of multiple small effects mapping to various genes rather than to the large effect of major genes (see C&O, p299-319).
Genetic analyses in both humans and mice suggest that multiple small-effect alleles contribute to sporadic CRC susceptibility.
Overall, all methods have less power to detect genes harboring multiple small-effect DSL, unless these are in high LD, in which case MGAS and GATES-MANOVA show sufficient power.
On the other hand, the DFE of deleterious mutations, in particular the proportion of weakly deleterious mutations, determine a population's expected drift load the reduction in fitness due to multiple small-effect deleterious mutations that individually are close enough to neutral to occasionally escape selection, but can collectively have important impacts on fitness.
The recent observation that multiple small-effect mutations might contribute to the stepwise emergence of drug resistance or to reducing the cost of acquired resistance, appears to reinforce this notion; such polymorphisms could be critical to the ability of the organism to survive very specific selective pressures that do not correlate with relative growth rate in vitro.
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