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The overall pattern of the NGS analysis of bantam suggests that Dicer cleavage can occur at multiple sites resulting in different isoforms.
The intensity of pain was moderate or severe, of prolonged duration and it arose at multiple sites, resulting in a significant limitation on everyday activities.
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The expression of chimeric guide RNAs (cgRNA) targeting single and multiple sites resulted in indel mutations in all the tested samples.
The NR2B subunit is the major tyrosine-phosphorylated protein in the PSD and its phosphorylation by src family kinases at multiple sites results in a docking site for various signalling molecules and enzymes [35].
While both these regions contained small indel events and multiple nucleotide degenerate sites, resulting in multiple plausible evolutionary histories, the posterior alignment distribution from BigFoot exhibited how our joint model reliably aligned all instances of the binding site together.
IL-1β has recently been shown to be a HIF-1-target gene since its promotor region carries multiple HIF-1-binding sites resulting in an enhanced expression under hypoxia [ 38].
The rs379675307 mutation causes a frameshift in SLC2A2 and also activates cryptic splice sites resulting in multiple aberrant exon variants.
The mutation leads to premature termination of translation and activates cryptic splice sites resulting in multiple exon variants also with premature translation termination.
Over half of all mammalian genes have multiple polyadenylation sites, or poly(A) sites, resulting in mRNA isoforms with different 3'UTRs and/or coding sequences (CDS) [16], [17].
In our case, the pain flare involved multiple sites and resulted in a transient decrease in performance status that lasted 10 days.
The use of five mosquitoes that probe in multiple sites must result in distribution of PfSPZ in the dermis and subcutaneous tissue in at least five different sites, and probably considerably more.
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