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To compare the inhibitory activity of these two peptides directly in the same experimental system, we used a primed peptide substrate from eIF2B (peIF2B) that contains a single phosphorylation site, to avoid complications arising from processive phosphorylation of multiple sites present in many GSK-3 substrates, including glycogen synthase and β-catenin.
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Several binding motifs for FOXO proteins were highly significantly enriched (q-value = 0.003 or less): for SOX2, multiple sites were present within 2 kb of the transcriptional start site.
A stochastic generation framework for simulation of daily rainfall at multiple sites is presented in this study.
In this model, the miRNA targets were classified into a few categories, with one class comprising of switch targets with multiple target sites presenting in the 3'UTR.
While no specific mineral-binding motif has been described for albumin, the interaction of this protein with apatite crystals has been attributed instead to the multiple calcium-binding sites present on this protein [62]-[64] [62]-[64]
In some countries (Bangladesh, Ghana, Burkina Faso, Kenya, South Africa) there were multiple sites involved which present interesting opportunities to consider within-country variations.
However, there are multiple GR binding sites present within the highly conserved orthologous region in the human sequence immediately upstream of the first exon of AKT1m.
Multiple actin binding sites, present as individual subdomains (e.g., C0, C1, C2, and the m-domain), may bind stoichiometrically (one subdomain per actin subunit).
In recalling influences on their practice's decision to participate in the registry (Table 3), respondents most often cited the need to consolidate records for patients who receive vaccines at multiple sites and, when present, state mandates for participation.
Four deoxyoligonucleotides were designed respectively based on the BAT1 (M1 and M2) or BAT2 (M3 and M4) nucleotide sequences and that of the multiple cloning site present in the pFA6a vector [23] (oligonucleotides used for this study are described in Table S1).
Our study demonstrates that R. felis is present in multiple sites in WA and was conclusively present in 1 of the 4 flea species collected (C. felis).
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