The presence of central sensitization or dis-inhibition in RLS sufferers might account for the high comorbidity of multiple site MSK pain.
The majority (74.9%) of older adults with pain endorsed multiple sites of pain.
Individuals who report chronic pain and multiple sites of pain are more likely to have MDD and are at higher risk of BD.
In addition to studies investigating single sites of pain, several previous studies have simultaneously examined multiple sites of pain.
Having multiple sites of pain causes more severe and disabling effects than having a single site of pain.
There are likely to be differences between individuals who select multiple sites of pain, which in essence must be widespread across the body, and those who select the single statement to agree that they have "pain all over the body".
8 Multiple sites of pain was also found to be significantly associated with poorer SPPB performance, after adjusting for age, sex, height, and weight, in 600 community-dwelling elders.
This study resonates with previous reports from much smaller study populations of an increased prevalence of chronic pain, including multiple sites of joint pain and widespread pain, in UK minority ethnic groups [ 2– 4].
Although these studies may provide useful clinical information concerning prognostic factors for local pain, recent studies carry implications that prognostic factors may be different for pain at multiple sites than for local pain at a single site in the upper limb [ 9].
There is also evidence from population surveys that multiple site problems dominate in persons with chronic musculoskeletal pain with only a quarter of those reporting chronic pain having it in a single site[ 23].
