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Multiple simultaneous interactions are those in which each interactant is responsive to more than one other at each moment in time.
The 125I-EGF – EGFR binding curves (irrespective of cell line) have strong signs of multiple simultaneous interactions.
One possible explanation for the large differences in affinity and the multiple simultaneous interactions is the presence of EGFR homo- and hetero-dimers.
Synergy between proteins in splicing may reflect cooperative binding to a functional element(s), or multiple, simultaneous interactions between the activators and other components of the splicing machinery (reviewed in [43]).
The presence of multiple ligand-binding sites within a protein affords opportunities for multiple simultaneous interactions, and is then able to significantly enhance or reduce the efficiency of ligand binding by an allosteric and cooperative (positively or negatively) manner, as compared with the binding to a single domain or motif.
Some proteins have multiple, simultaneous interactions ("party hubs") [ 16] while others have multiple, sequential interactions ("date hubs") [ 16].
Similar(49)
Indeed, we hypothesize that Tspan9 has multiple simultaneous interacting partners and functions as an interaction 'hub' within tetraspanin microdomains.
The high affinity of these IgMs might be due to avidity, which is the accumulated strength of multiple simultaneous binding interactions.
We exploit the concept of using hydrogen bonds to link multiple ligands for maintaining simultaneous interactions with polyvalent binding sites.
Of course there are many more complexities both host and parasite will be exposed to under natural settings, including constraints imposed by simultaneous interactions with multiple hosts or multiple parasite species and strains.
Usually, proteins interact with other proteins through regions (the interacting regions, IRs) that are specific to each interaction; therefore, simultaneous interactions with multiple proteins are possible (Kim et al., 2006).
More suggestions(15)
multiple simultaneous earthquakes
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multiple simultaneous communications
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multiple simultaneous aberrations
multiple simultaneous misalignments
multiple simultaneous errors
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