First, the contig could represent a combination of multiple simultaneous events, such as a pair of fusions joining three genes into a single transcript.
Because the frequency of the events being detected is typically low compared to the transcriptome size, and contigs that involve multiple simultaneous events are more difficult to characterize, we allow the user to limit the number of events that a reported contig can contain.
JMA plans to introduce the integrated particle filter (IPF) method (Tamaribuchi et al. 2014) to address over-predictions caused by hypocenter mislocation that results from multiple simultaneous earthquake events.
Current results do not provide insight into the utility impact of multiple simultaneous adverse events.
Compatibility treats polytomies as soft facts: if an input tree node has degree four or more, it is not because there were multiple simultaneous speciation events, but because there is not enough information to resolve the sequence of speciation.
However, based on the principle of parsimony, if orthologous genes are present in multiple species but absent in just one, a single gene loss event is more plausible than multiple simultaneous gene gain events [ 17, 18].
To Stratton this meant time had multiple dimensions, since simultaneous events could not be distinguished on the one past-present-future dimension of time alone.
This should be true for any signaling system that requires multiple simultaneous or sequential events to generate downstream outputs.
Second, mutation of any one of the basic PtdIns4,5P2-binding patches on α or β2, or the combined pair on μ2, strongly inhibits binding to membranes containing PtdIns4,5P2 and YxxΦ sorting motifs, i.e., high-affinity binding to YxxΦ-containing membranes requires multiple simultaneous PtdIns4,5P2-binding events on α, β2, and μ2 that can only occur when AP2 is in its open conformation.
We assume that the possibility of events involving backwards steps, and multiple simultaneous trait acquisitions constitute second-order effects which will not strongly influence the inferred evolutionary dynamics.
Furthermore, in the continuous birth death model, we need not worry about multiple mergers (Fu 2006), as there is zero probability of simultaneous events.
