This conclusion is supported by multiple MD simulations that demonstrate the possible accommodation of multiple CBZ molecules in the CYP3A4 binding pocket.
Ming and colleagues compared the history of rainfall from 1951 to 1999 with multiple climate simulations that showed how precipitation during the South Asian summer monsoon would change based on aerosols alone, greenhouse gases alone, natural forces alone, and all of these factors working at the same time.
The results of multiple simulations suggested that the polarity signals were necessary for cells to move forward and towards one another, causing them to cluster and shingle in a way that is qualitatively consistent with what has been observed experimentally.
These models are non-deterministic, are typically based on multiple simulations so that a range of behaviors can be established for a population, and have proven to be very useful in predicting emerging properties from complex systems [ 31- 36].
Introducing a distribution in the expression level to represent cell-cell variation within a clone, and averaging multiple simulations shows that population averaging for any one condition disguises the switch-like behavior and is indistinguishable from a graded responses, which is consistent with previous RT-PCR experiments [ 15].
This article reports improved B-factor prediction achieved by sampling the atomic positional fluctuations in multiple picosecond molecular dynamics simulations that use uniformly increased atomic masses by 100-fold to increase time resolution.
This requires the solution of the transport equations for arbitrary geometries, and leads to simulations that contain multiple simultaneous competing effects of visibility, directional and source flux functions, complex sputter yield flux functions, wide ranges of sticking coefficients for the reemission and redeposition functions, multilayered fronts and thin film layers.
As the model is stochastic, the program is designed to perform multiple simulation runs – that is complete a simulation for say a 50-day period, and then repeat this process a number of times.
And multiple simulations have predicted that mimicking the effects of a volcano would interfere with monsoons in Asia and Africa, potentially threatening water and food security for billions of people.
