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Many genes contained multiple significant sites, with an average of 4.7 CpGs per gene and a maximum of 114 CpGs.
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Site effects revealed by the statistical model are illustrated in Figure 4. Multiple regions showed significant site effects, implying a remarkable variability of 2dReHo across the 15 international sites.
Multiple significant GO terms are shown in Supplementary Table S6.
As indicated by the filled circles, responses recorded from multiple STG sites demonstrated significant differences between the AEPs recorded during the two conditions in the 500 msec period after voice onset (p<.01, PCA-manova).
Osteoporosis is a disease characterized by impaired bone quality, leading to increased fracture risk at multiple skeletal sites and significant morbidity and mortality [ 2].
Using an analysis method designed to identify the largest and most significant differences in DNA methylation at individual CpG sites, we identified multiple CpG sites across the genome exhibiting significant depression-associated differential DNA methylation.
Ambiguous tags are those that can be mapped to multiple genomic sites, each of which has significant sequence similarity with the tag, and thus it is difficult to distinguish the real site from all the possible sites.
Multiple donor sites have been described and each has significant disadvantages.
Boks et al. analyzed leukocyte DNA methylation in twins and healthy controls, and identified a significant genetic influence on the methylation of multiple CpG sites [30].
Testing the denitrification algorithms in these models with field data and independent isotope approaches in multiple sites could yield significant improvements in our understanding and estimates of denitrification at landscape and regional scales.
The likelihood of finding a statistically significant result increases further when the analyses simultaneously examine multiple cancer sites.
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