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CDH represents a major clinical problem because children affected with CDH have multiple significant morbidities affecting the gastrointestinal, musculoskeletal, cardiac and respiratory systems, as well as developmental delay.
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This paper considers how these principles apply to a case of a premature neonate with multiple significant co-morbidities whose mother wanted all possible treatments, and whose health care providers wondered whether it would be ethically permissible to allow him to die comfortably despite her wishes.
When factors were examined independently, multiple significant relationships (age, co-morbidity, hypoglycemic events, and weight gain) with overall and/or domains of treatment satisfaction were found.
Unfortunately, such assessment usually involves excision of the multiple nodes and can result in significant morbidities.
However, many of these new agents still harbor significant morbidities.
Osteoporosis is a disease characterized by impaired bone quality, leading to increased fracture risk at multiple skeletal sites and significant morbidity and mortality [ 2].
Studies have shown that DNA methylation is critical in the pathogenesis of fibrosis involving multiple organ systems, contributing to significant morbidity and mortality.
This group of mice exhibited significant morbidity in multiple experiments within a highly reproducible window 28-455 dafterfter infection).
Systemic lupus erythematosus (SLE) is a clinically heterogeneous autoimmune disease which affects multiple organ systems and causes significant morbidity and mortality [ 1].
Even in patients who survived, a clinical course complicated with multiple organ dysfunction leads to significant morbidity, costs, and use of already limited resources.
Oil based veterinary vaccines have previously been reported to cause a prolonged chronic granulomatous reaction with sterile abscess formation [ 11] that may result in significant morbidity requiring multiple operations for debridement [ 11].
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