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This is the traditional LCA assignment algorithm (Huson et al., 2007) where multiple significant matches from competing lineages are found.
Similar(59)
Multiple significant sequence matches from other spcies including mouse, Drosophila, C. elegans, pig, Fugu, Arabidopsis, and Anopheles gambiae were identified and are diagramed in Additional file 4 for CYFIP1 and NIPA2, respectively.
Several points suggest that this motif may well have functional significance relatively specific to the family 7a MT genes: a) Clusters of multiple, highly statistically significant matches are found within 500 bp upstream of the start codon of the four tested subfamily 7a MTs.
Because many TFs have very similar DNA-binding affinities, many of the known motifs in this database are similar to each other, so some discovered motifs have significant matches to multiple motifs in the database.
Scans with Hidden Markov Model (HMM) profiles built from multiple protein sequence alignments of TipE gene family members (see Methods) also produced no significant matches to tick or worm proteins.
"He's got multiple, significant concussions," on and off the football field, "and even probably multiple, subconcussive injuries playing football.… It really fits that picture".
This search returned 69 significant matches.
Match filtering is based on the intuition that unique significant matches are likely to be correct.
714 of the unigenes (54.75%) had significant matches (Table 1).
No significant matches are found with other known proteins.
However, these searches returned no significant matches (E < 1e-5).
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