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However, at the same significance level CAPE revealed multiple significant loci with main effects and a complex network of directed genetic interactions between loci influencing both SWD incidence and length.
EMMA analysis identified multiple significant loci (Figure 2A, P value < 1×10−5) on chromosomes 1, 2, 4, 6, 7, 8, 11, 12, and 15 (Table S1).
This suggests that CBB resistance has a complex inheritance with involvement of multiple significant loci distributed across all 11 chromosomes.
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When we allowed for multiple testing, ten of the 17 nominally significant loci reached the required level of significance (p < 2.8 × 10−3).
A recent methylome profiling study in major depressive disorder (MDD) did not identify any significant loci after correction for multiple testing; however, it successfully validated 60% of the top nominally significant differences.
Statistically significant loci were identified by applying a BY-FDR correction for multiple tests (false discovery rate; Benjamini and Yekutieli 2001).
Of the total 28 genome-wide significant loci, eight showed strong (P < 1 × 10−4) evidence for association with multiple expression probes.
Significant loci are indicated in Table 1.
Significant loci that located on 3' or 5' UTRs.
This was evident in the writings of the intelligentsia of the time who constituted a significant locus of the opposition.
Novel QTLs and significant loci-loci interaction were detected.
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