Multiple significant associations were obtained for many of the traits [27].
To estimate whether multiple significant associations from the same region were independent or simply due to LD, we tested hierarchically the associations by successively including the genotypes of stronger associations as covariates.
Using an expanded panel of response parameters coupled with a new and rigorous statistical approach to evaluating when a response is significant (see Materials & Methods), here we report on multiple significant associations between CD8+ T-cell responses in rectal mucosa and both plasma viral load and blood CD4 count.
For girls, however, we found multiple significant associations in age groups of 10-13 14-17 yearsears. 14-17 years
On the other hand, with treatment-related variables, multiple significant associations with survival were observed (Table 4).
We will capitalize on the large sample size and conduct conditional analyses to help fine-map the causal variant within a region showing multiple significant associations.
A survey conducted in western China [ 11] found multiple, significant associations between illness (both chronic diseases and inpatient treatments) and medical expenditure and other types of household consumptions.
In the analysis of the associations of illness conditions and medical expenditure with demographics, multiple significant associations were observed, and there are differences between the eastern and western regions.
The numerous genes that we detected have multiple significant associations across all three trait categories (Tables 1– 3, and 5), and the finding was possible to be explained by two hypothesis.
After highly conservative correction for multiple testing, significant association was only observed for the -1661G, -658T and -318T alleles (P = 0.031, 0.00010 and 0.017, respectively).
