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Finally, TRP channels integrate multiple signals such as temperature, osmolarity, pH changes, mechanical stress, etc.
Control of gastrointestinal motility is very complex involving multiple signals, such as nitric oxide (NO), gastrin, ghrelin, prostaglandins, 5-hydroxytryptamine (5-HT), dopamine, catecholamine, and acetylcholine [ 3, 4].
Human faces transmit multiple signals, such as faceness, eye gaze and emotional expression, all of which indicate valuable information during social interactions.
MTOR (mechanistic target of rapamycin) is a serine/threonine kinase that integrates multiple signals such as growth factor abundance with intracellular amino acid and ATP levels to coordinate cell growth and autophagy.
Certain miRNA families are indispensable for the establishment of the root system architecture [ 5], and are implicated in the transduction of multiple signals, such as nutrition, hormone and stress [ 6].
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Note that although we use the HAADF signal in this paper, it is possible to simultaneously acquire multiples signals, such as both bright- and dark-field signals.
We also found a significant number of genes with one pattern of differential expression in the tissue-specific extraction, and the opposite in the composite extraction, suggesting multiple signals from such genes within the composite structure.
In the case of TP53 as an important factor in cancer development it has long been known to be influenced by multiple upstream signals such as stress leading to different downstream effects such as apoptosis or development of cancer [10], [11].
Multiple stress signals, such as ROS and rapid increases in intracellular Ca2+, can trigger both apoptosis and macroautophagy.
Nucleotides are released by a variety of cell types in response to multiple stress signals, such as injury, hypoxia and inflammatory condition, etc. Further, the nucleotides are hydrolyzed by the enzyme cascade as follows: ATP/ADP into AMP by NTPDases, AMP into adenosine by ecto-5′-nucleotidase (known as CD73), and adenosine into inosine by adenosine deaminase [ 4].
The effect of curcumin is in part due to its ability to interfere with multiple signaling cascades such as cell cycle regulators, apoptotic proteins, pro-inflammatory cytokines, proliferative regulators and transcription factors such as nuclear factor-kappa B (NF-κB) and Stat3 [ 27].
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