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Upon arrival at the ALPM, multiple signals lead to initiation of cardiogenesis (reviewed in (Evans et al., 2010)), with expression of Nkx2.5, encoding an NK-class homeodomain transcription factor, being the earliest marker of myocardial progenitors in zebrafish and other vertebrates (Chen and Fishman, 1996; Komuro and Izumo, 1993; Lints et al., 1993; Tonissen et al., 1994).
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It has been reported that Bcl-2 members protect against multiple signals that lead to cell death, whereas Bax members induce apoptosis indicating that Bcl-2 family regulates a common cell death pathway and functions at a point where various signals converge [ 37, 38].
Multiple antennas lead to multiple signals emitted at the same time.
All together, the complex interactions between TSGs suggest that modulation of TSGs will likely affect multiple signalling pathways and lead to a complex drug response.
These phosphorylated tyrosines serve as the binding sites for several signal transducers that initiate multiple signalling pathways which lead to cell proliferation, differentiation, migration and metastasis, angiogenesis and antiapoptosis (Arteaga, 2002).
The development of diabetic cardiomyopathy is most likely induced by a range of systemic changes, which through multiple signaling pathways will lead to functional and structural derangements (Fig. 1).
In plant, evidence of plastid retrograde regulation is relatively well described, in which the GUN1 gene integrates multiple signals in the plastid and leads to ABI4-mediated repression of nuclear gene expression [ 5].
Because there is a wide diversity of splicing activity in the transcriptome, the multiple signals associated with an exon intron boundary may lead to the observation of a convoluted histone modification signal.
Activation of (multiple) signaling pathways eventually leads to biological responses [ 18].
For most applications, the environment leads to the arrival of multiple signals corresponding to emitted signal, signals which are scattered by the objects, and noise.
Meanwhile, multiple signals are flashing that the US hotel cycle is peaking.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com