At the transmitter side, the non-orthogonal characteristic pattern based on the multiple signal domains (including time, frequency, and space domain) is used to distinguish the users.
This may suggest there is a pressure towards the 'orphanisation' of some receiver-domain only genes, potentially because they have multiple signalling partners.
Upon binding of EGF, HER1 dimerizes and becomes phosphorylated on these carboxyl-terminal tyrosyl residues, which in turn act as docking sites for multiple signaling proteins that contain SH2 domains.
Dectin-1 recognizes β-glucan and induces multiple cellular functions through its cytoplasmic signalling domain, and is essential for protective immune response to Candida albicans and other fungi in mice and humans.
These findings shift the view of the mesocorticolimbic system as a singular pathway for reward to a system with multiple signals across a wide range of domains that drive value-based decision making.
A novel direction of arrival (DOA) estimation algorithm in the Dechirping domain is proposed, which is extended from the conventional multiple signal classification (MUSIC) algorithm in the time domain.
RGS14 is an RGS protein with multiple signaling regulatory elements, as it contains an RGS domain, tandem RBDs (Ras-binding domains), and a GoLoco motif [10], [11].
Signaling downstream of the activated receptor is induced by binding of SH2 and PTB domain-containing proteins, which stimulate multiple signaling pathways such as the Jak/STAT, PI3K/Akt, and MAPK pathways.
Anosmin-1 contains evolutionarily conserved fibronectin type III (FNIII) domains (Choy & Kim 2010) which may interact with multiple signaling complexes on the cell surface.
