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Targeting survivin may provide a novel perspective in cancer therapy by simultaneously disabling multiple signalling circuitries.
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Inhibition of multiple signaling circuitries through the abrogation of HSP90 may be an effective treatment strategy for highly recalcitrant tumors such as GBM [ 33- 35].
They say their brain also contains a spinal cord, signalling circuitry and even a retina.
Multiple Signal Classification.
DNA damage activates multiple signaling cascades.
SIRT1 also modulates multiple signaling factors.
RAGE ligation can activate multiple signaling pathways.
Many animals display multiple traits and assess multiple signals.
It remains unclear whether the oncogenic activity of BMP4, similar to that of IL-7, relies on autocrine signaling circuitries.
USP9X might also act as a regulator of the TGF-β pathway, another signaling circuitry of great relevance to cancer (reviewed in [58]), as witnessed by the fact that loss of USP9X abolishes multiple TGF-β gene responses [59].
Importantly, thrombin-induced and Ser/Thr kinase mediated activation of signaling circuitry in platelets is reversible.
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