SBL causes cancer-selective induction of apoptosis by multiple signaling pathways, which target RNA.
Riemondy et al. also used a variety of approaches to identify the molecules targeted by microRNA-203 in the skin, and reveal that it targets multiple signaling pathways, including components of the Ras pathway, to suppress cell proliferation.
Thus, HDAC inhibitors have the potential to target multiple signaling and repair mechanisms in the DNA damage pathway by targeting histones and non-histone proteins, as illustrated in Figure 1.
79 Studies are needed to determine whether EC targets multiple signaling pathways that trigger signaling crosstalk.
These probably include phosphorylation of multiple signaling proteins and their targets by numerous different kinases, and perhaps also changes in membrane excitability.
Retinoid X Receptors (RXRs), commonly known as ultraspiracle (USP) in insects [ 1], belong to the nuclear receptor superfamily and targets multiple signaling pathways.
Evidence supports that niclosamide targets multiple signaling pathways (NF-κB, Wnt/β-catenin, Notch, ROS, mTORC1, and Stat3), most of which are closely involved with cancer stem cells.
Because niclosamide targets multiple signaling pathways (e.g., NF-κB, Wnt/β-catenin, and Notch), most of which are closely involved with cancer stem cells, it holds promise in eradicating cancer stem cells.
Accumulating evidence suggests that niclosamide targets multiple signaling pathways such as nuclear factor-kappaB (NF-kB), Wnt/β-catenin, and Notch, most of which are closely involved with cancer stem cell proliferation.
Muscle wasting during cancer is a unique and multifactorial process which likely involves the differential regulation of multiple signaling pathways and downstream targets that together promote the wasting phenotype.
