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Through these complex and multiple signaling systems, adipose tissue is intricately involved in a wide variety of metabolic pathways.
Despite current evidence for the tight integration of multiple signaling systems in EC development, our data argue that the tip cell requirement for Wnt/β-catenin signaling operates through a mechanism that does not simply reflect a global modulation of VEGF and/or Notch signals.
The data from our study implicate the importance of comparative analysis in identifying the expression of OsAP77::GUS in each tissue and cell type as well as in response to different stresses in order to understand the complexity underlying multiple signaling systems.
The activity of MPs is impressive, perhaps related to their rich content of bioactive molecules, with their concentration in a single packet simultaneously triggering multiple signaling systems.
Occupancy of target genes in the Wnt, Hh, EGFR, JNK, transforming growth factor-β, PI3K/Akt, insulin, AMPK, Notch, Hippo, JAK/STAT, nuclear factor-κB, and target of rapamycin pathways indicates that Rbf1 may have the potential to exert broad and concerted regulation of multiple signaling systems.
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A key distinction between multiple signalling systems relies on whether the separate signals provide redundant information or not [ 5].
The PTHRP-R can couple to multiple signalling systems, including Ca2+/protein kinase C, cAMP and Ras/ERK pathways (Carpio et al, 2001; Miao et al, 2001).
Their activation leads to choices between multiple qualitatively different outcomes, such as stop, go, turn, exit, etc., thereby requiring intercalation of multiple signalling systems to gate the decision-making process at the level of the growth cone.
Signaling systems 3 and 4 are curious.
Multiple components of the FGF signaling system, including ligands, receptors, downstream effectors as well as proteoglycans are shown to localize to boundary cells in the chick hindbrain.
Multiple signaling pathways affect the circadian system, in ways that are likely to be adaptively significant.
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