Multiple signal transduction networks guide and coordinate these processes alongside quality control mechanisms to maintain protein homeostasis (proteostasis).
These data are novel observations showing that Stxs regulate multiple signal transduction pathways controlling translation in host cells, and support a role for eIF4E phosphorylation in maintaining host cell translation despite ribosomal intoxication.
The BCR-ABL protein has a constitutively activated tyrosine kinase, activating multiple signal transduction pathways.
Multiple signal transduction pathways are known to be involved in the remodeling of the heart [6].
Here, we show a dynamic role for a PDZ protein, modulating the thresholds of multiple signal transduction pathways in vivo.
Alternatively, as mitochondria are known to function in multiple signal transduction cascades, perhaps spindle-associated mitochondria helped to signal the location or timing of furrowing.
However, since these genes participate in multiple signal transduction pathways, their up-regulation may be related to inflammation rather than erythropoiesis [32].
The molecular mechanisms by which ZIP4 and zinc control growth and migration of cancer cells likely involves multiple signal transduction cascades.
Binding of stem cell factor (SCF) to Kit receptor tyrosine kinase activates multiple signal transduction components, leading to the activation of MAPK pathway [222], phosphatidylinositol 3-kinase, and Jak/Stat signalling [223].
Recent studies have revealed links between facial morphology and the action of multiple signal transduction pathways including those involving Calcium ion, Fgf, Shh, BMP, and Wnt signals [2], [75].
Multiple signal transduction pathways are activated by the binding of ephrins to Eph receptors, leading to actin rearrangements that can promote dendritic spine formation and maturation as well as spine retraction and loss [3], [8], [56], [58] [60].
