Reports [64, 65] have also shown that blockade of COX-1 activity results in multiple severe side effects, such as bleeding in the intestinal tract and impairment of renal function.
Unfortunately, adalimumab treatment is not totally safe, as multiple side effects have been reported recently such as reactivation of latent tuberculosis, endogenous endophthalmitis, retrobulbar neuritis, bilateral optic neuropathy, precipitation of systemic lupus erythematosus, secondary malignancies, lymphoma, and cardiac failures [ 32].
This potent anti-tumorigenic effect is mediated through multiple cellular pathways but is also accompanied by gastrointestinal side effects, such as colon inflammation.
It consists of multiple medications (including the daily injection) that can cause hideous side effects, such as deafness, psychosis, and liver failure.
Patient 1 received different psychotropic medications which were partially effective but accompanied by multiple side effects.
Duloxetine has a myriad of adverse side effects such as dose dependent blood pressure increases and multiple drug interactions [ 5].
As mTOR inhibition, such as achieved with rapamycin, is well known for its multiple side effects (Lamming et al., 2013), we confirmed that spermidine induces autophagy in T cells in an mTOR-independent manner.
4– 8 However, it is still difficult to cure patients with multiple myeloma; because most patients are elderly, resistance to novel drugs often appears, and severe side effects, such as peripheral neuropathy and serious infections, occur in many patients.
In contrast to monoclonal antibodies, TKIs inhibit multiple tyrosine kinase and were, in fact, associated with several non-VEGF-related biological and clinical side effects such as those investigated in our study.
