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Here we show that in peripheral blood 18% of the identified sex-biased genes are known to be regulated by estradiol, and several additional findings suggest that the sex difference in estrogen levels underlie multiple sex differences in gene expression.
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Multiple studies noted sex differences without reporting stratified data.
There have been multiple reports of sex differences in cerebral volume.
Our findings of multiple HE-driven sex differences would have been occluded if our sample population consisted of mainly OC users and/or LE women.
With these multiple methods of examining sex differences in OA, it is no wonder that the issue is far from settled.
The report also predicted that "over the next decade, the exploration of biological sex differences at multiple levels, from genes to hormones to complex systems, will be greatly accelerated".
Our finding of sex differences in multiple classes of metabolites is consistent with earlier studies on flies showing sex differences in lipid profiles (Parisi et al., 2011; Scheitz et al., 2013).
Multiple X and Y genes cause sex differences, but most of them have not been identified [ 16, 20].
They were further compared using a multiple regression analysis to adjust for age and sex differences between the cohorts.
There are multiple factors that can impact the appearance of sex differences in play, including housing conditions, prior learning, body weight, and dominance hierarchies.
While the sex differences in jealousy have been replicated in multiple studies, the theory is not without its critics.
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