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The Hobbit has faced multiple setbacks in the six years since the trilogy was first given the green light, including the loss of original director Guillermo Del Toro, a fire that destroyed a number of vital miniatures, and an enormous feud with a local New Zealand union that at one point looked likely to become a general actors' boycott of the project.
Guidant, meanwhile, has suffered multiple setbacks in its drug-coated stent program, and is now far behind its competitors.
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Among the industry's multiple setbacks over the years are swingeing tax increases on cigarettes in the West.
Huge, well documented, progressive improvements in neonatal outcomes have been interspersed with multiple setbacks.
Because of zoning constraints, he created multiple setbacks, with the building forming a wedding cake configuration at its center.
Conversely, the city suffered multiple setbacks with a recession from a series of failing markets (the "Panic of 1893") and the disastrous flooding of the Trinity River in the spring of 1908.
Mistresses Karen Yunjin Kimm) faces multiple setbacks as her book agent Barbara (Tia Mowry-Hardrict) isn't very encouraging.
Despite a global financial crisis, economic recession and multiple technical setbacks in the past two years, the world's major airplane makers, Boeing and Airbus, can at least take some comfort from the relative health and soaring ambitions of their Asian and Middle Eastern customers.
He later suffered setbacks in training.
A nascent housing recovery was offset by setbacks in manufacturing.
But his cause suffered setbacks in Rhode Island on Tuesday.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com