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The correlation of one serum measurement with exposure history is unknown for these chemicals, and we are unaware of prior studies that have examined multiple serum measurements of BPA or phthalates in individuals over time.
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For those with multiple serum 25(OH D measurements, we used the index or first measurement.
The lack of focused research and validation in randomized trials rather than ad hoc measurement of multiple serum markers in observational studies is also cause for concern related to the clinical applicability of these markers.
We generally agree with that conclusion, and further suggest that measurement of multiple serum variables within a related system such as mineral metabolism disorders or renal dysfunction may improve prediction modeling and correlation to cost.
We imputed serum measurements quantified as < LOD using a distribution-based multiple imputation procedure, to be able to create the summary exposure variables and to conduct the test of trend analyses (Lubin et al. 2004).
As there are eight serum measurements but only five organ measurements, serum measurements were omitted with respect to the corresponding (time-wise) organ measurement(s).
Cases I IV represent omitting 1, 2, 3, or 4 organ and serum measurements; case V represents omitting all eight serum measurements.
All serum measurements were performed in the same institution (UMCG).
Blood spot measurements were on average lower than both whole blood and serum measurements.
All serum measurements were taken on these.
JR carried out the MBL serum measurements.
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