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Serrated polyposis syndrome (SPS) is characterized by the presence of multiple serrated polyps spread throughout the colon.
Controls were individuals with multiple serrated polyps and no CRC.
Patients with multiple serrated polyps are at an increased risk for developing colorectal cancer (CRC).
Cases were individuals with multiple serrated polyps who presented with CRC.
Controls were individuals with multiple serrated polyps who had not developed CRC at the time of initial diagnosis with polyposis.
Hyperplastic Polyposis Syndrome (HPS) is a condition associated with multiple serrated polyps, and an increased risk of colorectal cancer (CRC).
Similar(33)
Serrated polyposis syndrome (SPS) is a rare condition of multiple serrated colorectal polyps and cancers.
Through exome sequencing of individuals who develop multiple sessile serrated polyps and/or serrated polyposis, we recently identified novel high-risk variants for the serrated pathway.
Of the 4 patients with CRC in whom no traditional adenomas were reported, one demonstrated multiple serrated adenomas (dysplastic serrated polyps).
Multiple lines of evidence now indicate that cigarette smoking is associated both with distal serrated polyps (which are thought to have a lower potential for malignancy) as well as with MSI-H colorectal cancer, which is largely proximal.
The presence of proximal serrated polyps and large (≥10 mm) serrated polyps (LSP) has been correlated with colorectal neoplasia.
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