Sentence examples for multiple sequencing approaches from inspiring English sources

Therefore, it is necessary to develop multiple sequencing approaches and platforms, including the third-generation long read technologies, high-quality long-insert clones and new assembly algorithms.

HER2 amplification was detected and further analyzed using multiple genomic sequencing approaches.

More traditional approaches for associating functional informations to proteins such as used by the PROSITE [9], PRINTS [10] and Blocks [11] databases extract sequence motifs using multiple sequence alignment approaches in order to infer information on key functional residues.

Duplicons within this complex mosaic cannot be readily uncovered by conventional multiple sequence alignment approaches.

Holin genes were identified using multiple sequence-similarity approaches as described in detail in the methods, and included identifications of transmembrane domains.

Multiple sequence alignment approaches to phylogenetic footprinting can be performed for a dramatically higher portion of genes (a 66% increase observed in this study) and lead to improved alignment quality (Kumar and Filipski 2007).

Here, we use a multiple-gene sequencing approach to assess the effects of human-aided dispersal on phylogeography of the tench Tinca tinca, a widespread Eurasian freshwater fish with a long history in aquaculture.

The present study uses a multiple-gene sequencing approach (Brito and Edwards 2008) and barrier-detection statistics to test whether the range-wide genetic variation of the tench shows a significant phylogeographic structure that can be explained by natural processes during the last glacial interglacial cycle.

After excluding eleven retrotransposon genes and nine hypothetical genes (Additional file 1: Table S1), the remaining 70 japonica reference genes were used to annotate genes in the other genomes using a multiple sequence comparative approach, as described in the Methods.

Because the numbers of trees to be searched increases in a factorial manner with the number of sequences included in the multiple sequence alignment, alternate approaches that use heuristic methods to accelerate the search for the optimal tree have been explored.

Our results show the versatility and usefulness of the combination of exome sequencing with whole-genome sequencing in studies of human population genetics and demonstrate that combining data from multiple sequencing platforms is an efficient approach to validate and supplement SNP calls.